A gene is introduced as cancer researchers in the human AT at Barts and the London Medical Association and the Faculty of Dentistry in the finding of liability. The study - published today in the journal Cancer Research (09 November) - paving the way for the development of diagnostic tests for early detection of cancer, and to prevent further treatment or at an early stage, the spread Cancer.
Dr. Muy - Tek Institute of Dentistry and Barts School of Medicine and Dentistry in London has led the researchers showed that a gene called FOXM1 inherent advantage of self-renewal of stem excessive growth of the property. The use of adult stem cells from the tissue of the normal computer's disease strains isolated cells in the laboratory to the abnormal expression of genes designed FOXM1 cellular level, which makes the fabric pattern in three dimensions culture to mimic human tissue in the laboratory, the excessive growth of cell regeneration. Cell culture system in three dimensions, scientists, without any provocation, and a person or an animal on the ethical issues surrounding the question of manipulation of human cells.
Levels of normal stem cells FOXM1 gene expression does not cause excessive growth of cells. Lead to abnormal growth FOXM1 because of illness, known as hyperplasia - an early sign of cancer before. This is considered an abnormal molecular events that represent cancer, lead the first step in the formation of the series.
Said: "We now know, plays a central role in cancer FOXM1, our goal is clinical benefit of molecular diagnostic tests for fundamental discoveries in the early stages of tumor growth, understanding could introduce discovered the origins of search on Cancer has announced new. chance to stop drugs effective against tumors or prevent cancer, a very young age. "
The study was jointly funded by the Wellcome Trust Award VIP Medical Research Council grants, Barts and the London Dental Institute for Medicine and Dentistry School of Economics, Queen Mary College, University of London and the Council of Norway research.
"FOXM1 The induction of human epithelial stem cells or progenitor cells" published November 9, 2010 Advanced Cancer Research Online
For more information please contact: Alex Fernando Communications Office Queen Mary University of LondonTel: 02078827910 Mobile: 07528711332 a.fernandes @ qmul.ac.uk
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