Stem | Secreted Protein Can Improve Heart Function Of Stem Cells After A Heart Attack Experience

Science Daily (November 18, 2010) - the heart tissue and stem cells into action to repair a heart attack damaged muscles and Duke University School of Medicine researchers found that the human body naturally produces a protein can potentially play a role in accelerating the repair of heart muscle. Since the proper dose, the secreted protein to the study of the Rat 2 Curly called relative (SFRP2 evidence) to prevent, heart failure and reduced collagen formation in layers after a heart attack in the thick scar tissue (also a myocardial infarction or heart attack).

Previously, the same researchers showed that this protein also record a response of heart attack death of cardiomyocytes.

These results of studies of human and clinical studies to assess the potential translation of new therapies can be implemented, "said Victor Dzau study, MD and James B. Duke professor of medicine and lead author.

"Our study showed that rats SFRP2 improve the detection of proteins significantly cardiac function after myocardial infarction key pumping chamber of the left ventricle," said Dr Dzau "We in the treatment received by lower doses to detect the death of heart muscle SFRP2, but also prevents collagen deposition direct thereby reducing the scars that affect the heart. "

The study was published in Science (PNAS) online in the previous version of the National Academy of Sciences the week of 15 published in November.

It also helps prevent thinning of the detection SFRP2 fourth week after injection of the heart wall. Since the process of healing (fibrosis) and organizations located in the heart of a heart attack one month ended remodeling in rats, the performance of the team to three or four weeks after the examination of the heart, myocardial infarction in rats echocardiography (ultrasound of the heart).

"We found that the detection zone SFRP2 Jianshao Zuoxin Qian Shi Weihua also evident in comparison Xinzang thickness ratio reduced 到 back wall," said Maria Mirotsou, Ph.D., co-author and professor of medicine.

Previously, Dzau's laboratory showed that the nature of stem cells in transgenic production factors act clearly called a heart attack, heart restored heart function in mice reduced the size of the area. The group as a living space in the heart tissue and repair of release detection SFRP2 these stem cells is a key factor identified, and this study shows that detection of the inhibition of collagen SFRP2 a possible candidate for production as well.

Other authors include lead author of the Wei River, Lunan Zhang Patriotic Ni, Ping Zhang, Lan Mao, and Richard E. Pratt, the study of Mandel Center for Hypertension and Cardiovascular Medicine at Duke all medical laboratories Dzau department.

This work by the National Heart, Lung and Blood Institute and grants financed Fred and Edna Mandel, small foundations and donations from the Foundation Leducq.

Editor's Note: This article is not intended to provide medical advice, diagnosis or treatment.

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