In a Walter and Eliza Hall Institute in Melbourne, Australia, researchers, new research shows that blood cells can communicate and influence the behavior of the "fathers" of adult stem cells.
Opening of the discovery of the "feedback" from a blood cell in the body of a stem cell disease, a disease caused by new forms of research and the potential for new diseases.
La Fuka Dr. Luo Lin, professor of molecular medicine Gexierdun Road, Warren, professor of cancer of the blood and the Ministry of Alexandria led the research.
Hilton said the findings of the National Academy of Sciences of the United States was released today, reveals that the blood between the people t the relationship is not known to exist between cells.
"We know that the blood stem cells give rise to all mature blood cells, but the standard assumption that external factors to control the production of blood cells and isolated existence of the two groups," said Professor Hilton .
"This study shows that the change of mature cells actually communicate with their gene expression in stem cells and influence their behavior."
The researchers found that the disease can lead to disruption of cells in the feedback loop and blood stem cells have a profound impact.
The discovery was made in the study of the transcription factor MYB, inhibition of platelet production, loss of animal models.
Mr de Graaf said the loss of MYB genes means that animals are kept in the blood, causes the signal of stem cells in the control changes to an elevated platelet count.
"Stem cells do not retain, but a" rest "until it is needed, he said he would continue the cycle of production of mature blood cells," said Mr de Graaf said. " Stem cells, blood disorders, and finally works out of development because there are not enough stem cells are cells generate new red and white. "
The team can use a new generation of genetic technology to identify genes into blood stem cells bad signature signal characteristics of these genes caused the cells to diagnose and assist in future treatment of diseases.
said: "If we can begin to understand the genetic conservation of stem cells and the production of blood cells important to you, you're dealing with focus on improving technology and transplantation of blood disorders, the forms" said de Graaf.
Hilton said the failure of stem cells with the patient, the future can benefit.
"We want to do is, if the fact that these cells are due to some mature blood cells and stem cells misunderstandings and new approaches to this disease, the ability to manage the track," he said.
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