Stem | The Researchers Found That Patients With Acute Myeloid Between The Gene And Stem Cells Results In Certain Activities Of The Association ...

"In many cancers, appears specific subsets of cells initiate and maintain the unique ability of the tumor. For this master cells of the most powerful support of cancer in immunodeficient mice, suggesting that transplantation of human acute myeloid leukemia (ALD) to leukemia stem cells to promote self-renewal, "according to background information in the article. "The cancer stem cell model of the most important implication is the need to eliminate ECJ destroy cancer cells and treatment of patients. Cartel Although early trials of cancer in men over the model and significance clinic has not yet been fully established. "

Andrew J. Gentile, PhD, Stanford University, Palo Alto, California, and colleagues of gene expression Dyna-rich (high concentration) of samples of primary leukemia and normal subgroup of patients (active) profile. Copies in the Medical Center of the United States in April 2005 to July 2007. Other anti-money laundering fixed tumor profile data of the 4 groups (n = 1,047) of independent groups were also evaluated.

Researchers have 52 gene expression in AML samples separate cell sorting Dunnan people already wealthy. Summarizing the results of a large tumor samples LSC leukemia, the expression of these genes in the 4 groups of patients regardless of clinical efficacy. ICL scores with poorer general free fall of no return, or survival of these patients with a normal karyotype or chromosomal abnormalities (group average of chromosomes).

"The absolute risk of death three years later to participate in the LSC group of 57 percent as the group of 78 LSC. Another available data on the event-free survival rate was 70 cases of patients with normal karyotype, the risk of tail events by 3-year low of 48 percent of the 81 groups divided into groups Dyna Dyna percent higher rate, "the researchers wrote.

The LSC also marked with the main reaction induced by chemotherapy because of the sharp decline in the rate of discount points Nan Liedun strong correlation.

"In this study we found that the expression of the partition a rich subset of genes with the LSC is an independent prognostic factor in AML, high population LSC in a number of independent findings of negative consequences. ... If the prospective validation, "said Ming Client Dunnan in routine clinical practice can be integrated with the prognosis of patients at risk of leukemia and the policy based on stratified randomized clinical trials or predict."

The researchers added that the study provides the first direct word, a large number of leukemic cells to initiate the signature (genes at the level of activity of the cells is different from the other group) and diagnostic samples involved in the profiles of the expression signature that is associated with the link the clinical and pathological patients as possible. "Finally, this model has a significant impact on the treatment of cancer, particularly in terms of achieving the cure of cancer stem cells must be eliminated. To achieve this objective in the fight against money laundering LSC new targeted therapies."

1537-1538. 2010, 304 [24]: 2706 to 2715th

source journal American Medical Association

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